Background: Atopic diseases are a imunological diseases linked by an immune system respond that has an opposite effects towards patient’s alergen that has a genetic predisposing factor to develop the atopy. Childhood atopic disease includes atopic dermatitis, allergic rhinitis, asthma, and food allergy. A research from International Study of Asthma and Allergies in Childhood (ISAAC) third phase in 2012 shows the prevalence of allergic disease in a various number through 98 countries. Some studies shows the correlation between smoking cessation and allergic diseases. A cohort study in swedia shows the early tobacco exposure can cause an increase of IgE sensitization through food allergen and indoor inhalant in children. An ISAAC questionaire study – based in Malta also shows a passive smoking can cause a harmful effect to the allergic condition in the children. Objective: to reveal the exposure to smoking towards atopic diseases in childhood. Methods: Subjects of the research were recorded by using informed consent and ISAAC questionaire to determine the presence of atopic diseases and exposure to smoking wether passive or active (n = 86). Results: Subjects with atopic diseases were classified into 4 groups: groups with a history of Allergic Rhinitis, Asthma and Atopic Dermatitis and food allergies. There was a passive exposure to smoking, that is 62 children (72.1%), with significance (p=0.156) for subjects with a history of allergic rhinitis, while for subjects with Asthma history, a passive exposure to smoking results of 23 children (26.7%) was obtained, with significance (p=0,409). Moreover, subjects with a history of Atopic Dermatits, a passive exposure to smoking results of 23 children (26.7%) was also obtained with significance (p = 0,901) and at last, subjects with a history of food allergy, a passive exposure to smoking obtained was 8 children (17.4%) with signification (p = 0,401). Conclusion: It can be concluded that there is no effect between exposure to smoking towards atopic diseases in Childhood for the subjects being examined.