Reasearch entitled "the Analysis of the factors that Affect crop production of rubber (Hevea brasiliensis) at PT.Melania-Indonesia (Palembang) " aims to determine the effect of plant production, rainfall, and labor on fluctuations in rubber production and to obtain the most production factors dominant effect on fluctuation of rubber production in PT.Melania-Indonesia. This reasearch was carried out in January to March 2018, using the method of survey data obtained with scunder from PT.Melania-Indonesia, such data include extensive crop production, rainfall and labor. Data analyzed by the method of multiple linear regression analysis (Cobb-Douglas). The results of the reasecrh showed that all the variables used together effect on rubber production in PT.Melania-Indonesia. but individually (partial) variable extensive crop production, rainfall and labor give no effect on rubber production.