This research is a study that analyzes the strategy of anti-drug campaign conducted by National Narcotics Agency of Yogyakarta Special Region Province (BNNP DIY), through arts and cultural approach. The purpose of this study is to describe the strategy of anti-drug campaign through art and cultural performances conducted by the National Narcotics Agency of the Province of Yogyakarta Special Region Province on period 2015-2017. The research method and type used in this study are qualitative research method and case study type. This research is located in the National Narcotics Agency of Yogyakarta Special Region Province (BNNP DIY) office. The sources of research data are derived from interviews with informants, documents, and photos documentation. The data validity test used triangulation sources, which are comparing and checking back the degree of confidence on information obtained through different times and tools in the qualitative methods. The results of this research shows that the anti-drug campaign strategy through art performance and culture held by BNNP DIY in 2015-2017 are one of the unique campaign strategy, contrary/ different to the anti-campaign activities other drugs. BNNP DIY involving perpetrators of art as the anti drug campaign communicators, and became the hallmark of the anti drug campaign activities through arts and cultural performances. But the weakness of the anti drug campaign activities through cultural and artistic performances of the period 2015-2017 are the publication activities that need further evaluation, and does not have a clear success indicators yet.