This research analyzes how effective utilization as Instagram media socialization P4GN conducted by the National Narcotics Board of Yogyakarta Province in January 2017 – March 2018. National Narcotics Board of Yogyakarta Province implement P4GN program aims to improve the immunity of the community against the dangers of drug abuse and illicit trafficking.The purpose of this research is to know the effectiveness of utilization of media dissemination as Instagram P4GN National Narcotics Board of Yogyakarta Province and provided a number of recommendations to the agency. This research method using quantitative survey because the research data in the form of numbers and analysis using statistics and aspects of measurement objectively against social phenomena. The object of this research is the National Narcotics Board of Yogyakarta Province and the subject of this research is followers account Instagram @ bnnp_diy. The results of this research show that utilization of media dissemination as Instagram P4GN conducted by the National Narcotics Board of Yogyakarta Province has been effective, which is characterized by linear regression coefficient value is y = 0, 463X + 60.32. Instagram Utilization as Media Socialization of P4GN National Narcotics Board of Yogyakarta Province has been effective because because Instagram user is still a necessity in finding P4GN information. In addition in terms of quality, Instagram BNNP DIY in providing information according to followers Instagram @bnnp_diy has been actual, factual and clear in delivering. However, the researchers found that followers Instagram account @bnnp_diy still less enthusiastic in commenting post, repost and Direct Message. In addition researchers have also found that the frequency of BNNP DIY in the post P4GN on Instagram information is still lacking. It makes use of Instagram as a media of P4GN socialization by National Narcotics Board of Yogyakarta Province become effective because it is supported by statistic percentage gain percentage of each indicator such as: quantity, quality of social media of Instagram and cognitive, affective and konatif effect of socialization is quite good