EFFECT OF BISPHOSPHONATE RISEDRONATE HYDROGELS TOWARDS NUMBER OF OSTEOCLAST DURING RELAPSE TOOTH MOVEMENT
PUDYANI, PINANDI SRI
ANA, IKA DEWI
UTARI, TITA RATYA
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Relapse (tooth movement in its original position) has made undesirable result of the orthodontic treatment. It became a complex problem in orthodontic which caused by many potential factors. Eric et al. in 2003 reported that relapse is commonly caused by intrinsic factor related to periodontal ligament and alveolar bone, but to some extents, extrinsic factors such as face structure growth, soft tissue pressure and interdigitation are also believed to influence the process. Relapse happen immediately after orthodontic appliance removed and decrease its speed after three days, this movement usually followed by alteration the amount and distribution of osteoclast. Osteoclast is the multinuclear cell origin of differentiation granulocyte-macrophage progenitor cell in bone marrow. It has a function for bone remodeling specifically resorbtion, when it completed osteoclast will be apoptotic. One of the strategies to manipulate bone remodeling known in orthodontics area is by the application of an analogous phosphonate drug to inhibit bone resorption, e g. bisphosphonate. Biphosphonate risedronate is Nitrogencontaining bisphosphonate that has an ability to adhere calcium and inhibit differentiation of osteoclast. In this study, we proposed hydrogel system as described by Saito and Tabata. Bp-risedronate hydrogel is type of Drug Delivery System that has local effect on inhibiting resorbtion alveolar bone.