This study aims to examine the influence of BI Rate, Inflation, Operational Costs & Operating Income (BOPO), and FDR on Return On Assets (ROA) as projections and profitability of Bank Panin Dubai Syariah which has listed shares in the Indonesia Stock Exchange office. The data used in this study is secondary data. Secondary data is data obtained from the data of Bank Panin Dubai Syariah Monthly Publication Financial Reports taken from the 2014-2017 period and the official website of Bank Indonesia as well as data on the BI rate and inflation. The data analysis techniques used was error correction models and Eviews 8. The ECM test has several stages, namely stationary test and cointegration test. Then the F test and the T test were carried out. The results of the F test of this study shows that the BI Rate, Inflation, BOPO, and FDR variables had a simultaneous effect on ROA. Then the results of the T test of the BI Rate, Inflation, and FDR variables do not have a partial effect on ROA. While the BOPO variable has a negative and significant effect on ROA. Furthermore, the R2 value is 69% which means that the dependent variable can be explained by the independent variable, while the remaining 31% is explained by other variables not used in this study.