Geriatric patients generally experience susceptibility to various diseases because of decreased function of organs and one of them is a nervous disorder. The inaccuracy of the use of drugs acting on the nervous system based on the Beers Criteria 2015 is widely reported. This study was conducted to determine the prevalence of prescribing drugs with the diagnosis of neurological disorders in geriatric inpatients based on Beers Criteria 2015 at Rumah Sakit Umum Daerah Panembahan Senopati Bantul. This study was an observational study and data collection was conducted retrospectively based on medical record data of geriatric inpatients with diagnosis of neurological disorders at RSUD Panembahan Senopati Bantul from January - December 2016. Sampling was done by systematic random sampling. Data were collected from 153 medical records of patients which included in inclusion criteria. Data were analyzed under the guidelines of the American Geriatrics Society Beers Criteria 2015. The results showed that from 153 geriatric patients in RSUD Panembahan Senopati Bantul included in the inclusion criteria, 85 patients (55.6%) were identified Potentially Inappropiate Medications (PIMs). The PIMs analysis included four categories: drugs to be avoided from geriatric patients categories with the highest percentage is diazepam with 24 usage (33.3%) and nifedipin immediate release with 10 usage (13,9%), drug to be avoided based on disease or a certain syndrome categories with the highest percentage is ranitidine which were used for 5 patients with dementia (62.5%), drug used with caution in geriatric patients categories with the highest percentage is furosemide with 37 usage (71.2%), and drugs interaction to be avoided categories including diazepam with ≥ 2 CNS medications from 4 patients (66.7%), dexamethasone with ketorolac from 1 patient (16.7%), and tramadol with amitriptiln and morphine from 1 patient (16.7%).