The 6-hydroxy-2-(pyridin-2-yl)-4H-chromen-4-one is a modified compound of 1-(2,5-dihydroxyphenyl) -3-pyridine-2-yl propenone in an oxidative manner. The 6-hydroxy-2- (pyridin-2-yl)-4H-chromen-4-one compounds include flavone compounds. Flavones are flavonoids that are widely distributed in plants. This flavon also has activity as antiinflamsi, antikanker, antivirus and others. The purpose of this study was to find a 6-hydroxy-2- (pyridin-2 il) -4H-chroman-4-one compound which can be synthesized from the oxidation of 1- (2,5 dihydricsifenol) -3-pyridine-2-yl-propenone) using a catalyst I2 in DMSO with the help of microwave radiation. The method performed in this synthesis is the oxidation of the 1- (2,5- dihydroxyphenyl) -3-pyridine-2-yl propenone compound with the I2 catalyst in DMSO using microwave for 2-4 minutes in 140 watt power. Thin Layer Chromatography (DLC) -Densitometry analysis to test the most optimal reaction conditions method to produce new compound products. LCMS analysis is used to determine the molecular weight of new compounds that are formed. Results of crude product analysis using KLT-densitometric test obtained optimal reaction conditions with an area of 14413.4 and Rf 0.81. Optimal reaction conditions formed on the raw material mass 124.5 mg, mass I2 128 mg, and DMSO 3 drops in microwave time 2 minutes with 140 watts of power. The LCMS analysis at 0.47 minute retention obtained molecular weight of 239.90 m / z with a 100% concentration allegedly corresponding to the molecular weight of 239 6-hydroxy-2-(pyridin-2-il)-4H-chromen-4-one compound of the molecular formula C14H9O3N.