Background: The Multiple Choice Question (MCQ) exam is the most objective and numerous test of method in the context of students understanding and knowledge. The MCQ exam has a big influence with the figure of 35%. There are factors influencing MCQ result there are internal factors such as health, intelligence, readiness, fatigue, and external factors include how to educate parents, teaching materials, student learning method, and mass media. Purpose: This study aims to analyze the factors that affect the results of MCQ on students of Nursing Science Program Faculty of Medicine and Health Sciences University Muhammadiyah Yogyakarta. Method: The type of this research is non experiment with quantitative method and using correlational descriptive design. The approach used is cross sectional approach. Respondent in this research is 213 respondents and using proportional stratified random sampling technique. Data analysis used chi-square test and continued with logistic regression test. Result There are significant relationship between health (p = 0,023) and intelligence (p = 0,051) with MCQ result. There are meaningful relationship between health (OR = 2,085) and intelligence (OR = 0,493). Conclusion: The factors that influence the MCQ result is health and intelligent and health is the most dominant factor which influence MCQ result.