Background: The concept of Academic Health Center (AHC) is a combination of education, research and health services functions. Faculty of Medicine and Health Sciences Universitas Muhammadiyah Yogyakarta (FKIK UMY) is educational institution with study program of Medical, Dentistry, Nursing, and Pharmacy. The concept of AHC is potentially applied in Indonesia especially in FKIK UMY to improve the quality of human resources in accordance with Competency Standard of Indonesian Doctor 2012 (SKDI 2012) and WHO 5 star doctors. The objective of this research is to determine the role of FKIK UMY towards preparation of human resources in realizing the concept of AHC. Subject and Method: This study used a qualitative research design by interviewing 6 respondents from representatives the Dean of FKIK UMY, several teaching staff of Medical and Nursing of FKIK UMY. This research was conducted in April - May 2018 which is located in FKIK UMY. The results of interview transcripts were processed using descriptive method. Result: The role of FKIK UMY in attempt to realize the concept of AHC based on 4 aspects consisting of organizational aspects namely bureaucracy, policy aspects namely regulations, financial aspects namely financial support, and aspects of resources namely competent human resources and teaching hospital. The concept of AHC may facilitate the role of FKIK UMY in implementing the Tridarma of higher education and it is expected to have merger organization among FKIK UMY manager with teaching hospital manager and involving the role of Health Advisory of Muhammadiyah Central Board (MPKU). xiii Conclusion: The role of FKIK UMY has just reached the stage of legal collaboration and coordination with MPKU and teaching hospital to realize the concept of AHC. Keywords: FKIK UMY, Tridarma of Higher Education, Academic Health Center