Controlling of nosocomial infections in hospitals is one indicator of hospital service quality. The occurrence of phlebitis increases because of the high use of intravenous therapy performed in almost all health care units, especially the use of intravenous antibiotik therapy. This study wanted to know the effect of intravenous antibiotik risk to the occurrence of phlebitis at Panembahan Senopati General Hospital of Bantul. This research is a non-experimental research with observational quantitative with Cross Sectional design. Data collection was conducted prospectively in June 2018. The data were processed using Pearson Chi-Square test. The subjects of this study were inpatients in 4 adult wards of RSUD Panembahan Senopati Bantul who got the intravenous line and parenteral antibiotik therapy. From 60 respondents whom examined, there were 5 respondents (8.3%) who experienced Early Stage Phlebitis. Two of them received Ceftriaxone, while 3 others each received Cefotaxime, Ciprofloxacin, and Meropenem. The result of Pearson Chi-Square test was p value = 0.610 which means there is no effect of antibiotik parenterally on the incidence of phlebitis in hospitalization Panembahan Senopati Bantul. Keywords: Antibiotik, intravenous antibiotik, phlebitis