Background: Stroke remains one of the major health problems, not only in Indonesia but also in the world. The improvement of stroke service process is expected to support better outcomes of stroke service quality. One of the clinical management used is the implementation of clinical pathway. The purpose of this study was to explore the implementation of CP cerebral infarction in the inpatient unit of Bantul PKU Muhammadiyah Hospital. Method: A mix-method study with case study design. The quantitative sample is the patient's total cerebral infarct medical record (June 2016-November 2016, n = 27) and ICPAT checklist. Qualitative samples are doctors, nurses and people involved in the implementation of CP cerebri infarction obtained from deep interview with purposive sampling technique. Results and Discussion: ICPAT dimension 1 (CP format) content and quality are good. Dimension 2 (CP documentation) moderate content and good quality. Dimension 3 (CP development) moderate content and good quality. Dimension 4 (implementation CP) content and quality are poor. Dimension 5 (maintenance CP) content and quality are moderate. Dimension 6 (role of organization) content and quality are good. Compliance rate of completeness of CP form is 22% and content of CP is 0%. Most constraints due to busyness of the officer and time constraints. Conclusions and Suggestions: The cerebral infarct CP implementation compliance level was poor. Need socialization, training, regular evaluation and full time facilitator. Keywords: Implementation, Clinical Pathway, cerebral infarction