Background: Patient Centered Care (PCC) has become one of the standard services in hospitals in support of the Government of Indonesia's National Program, one of which is reducing maternal and infant mortality and improving maternal and infant health. Not much research on PCC in Indonesia, especially related to the effectiveness of PCC application in reducing the level of anxiety and improve patient satisfaction after Cesarean Section surgery. Methods: This study was an Experiment Quasi, involving 35 respondents (controls) and 31 PCC respondents (intervention) in postoperative Cesarean Section patients. The research instrument used a State Anxiety Inventory and SERVQUAL modification methods questionnaire. The research was conducted in RS PKU Muhammadiyah Bantul on June-August 2018. Data analysis using independent sample t-test. Results and Discussion: From the measurement results of different test levels of anxiety from the control group (mean = 62.8571) and PCC (mean = 45.4667) showed the results of sig. 2-tailed = 0.001, and the test of the level of satisfaction between the control groups (mean = 76.3143) and PCC (mean = 84.9677) was obtained by sig. 2-tailed = 0.003. Different tests are said to be meaningful if p value <0.05. Conclusions: There are significant differences in anxiety and satisfaction levels in both groups. The results showed that PCC can reduce anxiety levels and increase patient satisfaction. Keyword: Patient Centered Care, anxiety, satisfaction, Cesarean Section