Coronary Artery Disease (CAD) is main cause of mortality in heart disease (WHO, 2011). Complex therapies are needed in order to treat the CAD such as pharmacology, Percutaneous Coronary Intervention (PCI) to widen the clogged artery, and lifestyle intervention that aimed to decrease the severity of CAD and restenosis. Pharmacology complexity therapy which is received by CAD patient could cause Adverse Drug Reaction (ADR) events. Therefore, this study aimed to identify the respon of CAD patients after PCI therapy at RSUD Panembahan Senopati Bantul Yogyakarta . This research was a descriptive analysis using retrospective data with total sampling method at RSUD Panembahan Senopati Bantul Yogyakarta. The samples were outpatient CAD after PCI in RSUD Panembahan Senopati Bantul Yogyakarta which fulfilled the inclusion criteria from January to September 2017 which were 65 patients. The result showed that responses of CAD patient after PCI including restenosis symptoms (70,77%), consist of 1 restenosis symptom (43,08%) and 2 restenosis symptoms (27,69%), uncontrolled lifestyle intervention such as abnormal cholesterol total (58,62%), abnormal LDL cholesterol (93,10%), abnormal HDL cholesterol (72,41%), abnormal triglyceride (70,69%), abnormal blood pressure (72,22%), abnormal HbA1c (50%), and adverse drug reaction (4,62%).