This research was conducted in Pharmaceutical Warehouse of South Bengkulu Health Office of South Bengkulu Regency. South Bengkulu Pharmaceutical Warehouse Resilience Very Useful By Pharmaceutical Warehouse Health providers in puskesmas throughout South Bengkulu Regency to buy medicines for health services, prevention and eradication of diseases among each puskesmas throughout South Bengkulu Regency. The purpose of this research is to produce information system design based on ASP.NET MVC 5 which is useful for Pharmaceutical Warehouse of South Bengkulu in facilitating transaction process and minimize mistake in making transaction report in Pharmaceutical Warehouse of South Bengkulu. Based on the results of the test can be concluded that the application made this can help the process of checking, recording and printing reports in Pharmaceutical Warehouse South Bengkulu.