Histologic differentiation is one of the best prognostic for breast cancer, which is a morphological assessment of tumor biological characteristics and has been shown to produce important information related to clinical behavior of breast cancer with differentiation I (good), II (moderate), III (bad). Family history is one of the prognostic factors for breast cancer patients because of the various genes that are passed down through family history there are BRCA 1, BRCA 2 and p53 genes can be observed and a prognostic factor on how the development of the cancer. Knowledge of family history relationship with histologic differentiation can be used as prognostic factor and therapy implementation. This research is aimed to find out whether there is a relationship between family history with histologic differentiation on female breast cancer. Methods : This study used a cross sectional design of 37 patients with a diagnosis of breast cancer that has been done histopathologic examination and family history data taken from the medical record. With the period from 6 March to 6 June 2017 at Panembahan Senopati General Hospital in Bantul. Analysis using data with Chi-square test done gradually include univariate and bivariate analysis. Result : Number of samples were 37 people with age range 28-75 years with demographic age <50 years counted 15 (40.5%), age> 50 years was 22 (59.5%). Histology differentiation was 0 (0%), histology differentiation was 18 (48.6%) people, and histology differentiation III were 19 (51.4%) people, and there were family history 15 (40.5%) people, and no family history as many as 22 (59.5%) people. The value of statistical test of association between histologic differentiation with family history of breast cancer showed no significant result (p = 0,297). Conclusion :There was no association between family history and histologic diferensiasi of breast cancer.