Background. Diabetes mellitus is one chronic disease that can cause systemic complications such as diabetic foot ulcer that affect patient spirituality level. Objective: The objective of this study was to describe the level of spirituality among patient with diabetic foot ulcer based on the demographic characteristic including gender, age, formal education, marital status, duration of DM, severity or grade diabetic foot ulcer and type of care in RS PKU Muhammadiyah Yogyakarta Method: This study was desciptif study with cross sectional approach. The sampling technique was accidental than involved 26 responden. The Data were collected by using Spirituality Well-Being Scale (SWBS) Indonesia version that was valid (r=0,521-0,759) and reliable (r= 0,892). The data analyzed using descriptive statistic. Results: The level of spirituality among patient with diabetic foot ulcer was high among 23 respondents (88.5%) and moderate among 3 respondents (11.5%). The High spirituality mostly found in the those who aged from 40-60 years (16 respondents, 61.5%), womens (13 respondents, 50.0%), graduated from senior hifh school (7 respondents, 26.9%), married (20 respondents, 76.9%), duration of DM more than 3 years (21 respondents, 80.8%), had diabetic foot ulcer grade 1 (12 respondent, 46.2%), in- patient care (18 respondents, 69.2%). Conclusions:Most of The patient with diabetic foot ulcer in RS PKU Mumahammadiyah Yogyakarta have high spirituality. Nurses, health care provider and families are expected to support the patients to maintain and increase the patient spirituality level. Further research is needed to examin the effect of certain program to improve patients spirituality level.