According to the American National Health and Nutrition Examination Survey between the period of 1999 to 2004 the prevalence of stage 1 to 4 Chronic Renal Failure (CRF) increased significantly when compared with the period of the 1988 to 1994 survey. There are some factors that influence the high incidence of CRF include age, hypertension and diabetes mellitus. The large number of comorbidities and complicated therapeutic management led to a high incidence of Drug Related Problems (DRPs) in patients, especially patients with CRF. Therefore, this study aims to determine the incidence of DRPs in the therapy of inpatients of Chronic Renal Failure (CRF) at PKU Muhammadiyah Gamping Hospital from January to December 2016. This research is an observasional non experimental descriptive design study. The data of CRF patients at PKU Muhammadiyah Gamping Hospital was conducted retrospectively from 45 medical records of chronic renal failure patients from January to December 2016. The collected data was analysed by using literature analysis such as KDIGO 2012, Drug Interaction Facts 7th edition 2010, and Drug Information Handbook. The results of identification of DRPs in the management of CRF patients at the inpatient installation of PKU Muhammadiyah Gamping Hospital from January to December 2016 showed that there were 22 patients (48.88%) who experienced DRPs from a total of 45 patients. There were 30 events of DRPs consisting of 18 incidents (60%) of drug needed, 2 incidents (6.6%) of wrong drug, 0 events (0%) of unnecessary drug therapy, 0 incidence (0%) low dose , 0 events (0%) high dose, and 10 events (33.33%) of drug interactions.