This study aims to determine the effect of Monthly Production Index of Medium and Large Industry, Money Supply (M2), Exchange Rate, and Gold Prices on Jakarta Islamic Index (JII) as dependent variable.The data by using monthly data from January 2015 until December 2017 taken from Indonesian Financial Statistics Bank Indonesia, Indonesia Financial Service Authority, Central Bureau of Statistics, and goldprices.org. This study used Multiple Regression processed with Eviews 7 to influence analysis of independent variables on dependent variable.The result of this study shows that independent variables Monthly Production Index of Medium and Large Industry and Gold Prices have positive realtion but insignificantly influence JII. While, M2 has positive relation and significantly influences JII and Exchange Rate has negative relation and significantly influences JII. R2 value 82,03% means independent variables (Monthly Production Index of Medium and Large Industry, Money Supply (M2), Exchange Rate, and Gold Prices) influence dependent variable (JII) by 82,03%, and 17,97% of dependent variable is influenced by independent variables outside the model.