Socioeconomic factors, Attitude and Behavior As Critical Determinants for Dengue Prevention Program in Sleman, Indonesia Farindira Vesti Rahmasari1 , Tri Wulandari Kesetyaningsih1, Dian Kartikasari1 1Department of Parasitology, School of Medicine, Universitas Muhammadiyah Yogyakarta,Yogyakarta,Indonesia E-mail of the corresponding author: farindira.vesti@gmail.com Background Socioeconomic, attitudes and behavior are the three factors are thought to play a role in determining Free Larvae Index in Sleman, Yogyakarta, Indonesia. Socioeconomic level that varies between Depok District and Moyudan District in Sleman are indicated by the type of education and the vary of the job . The dominant population in the Moyudan district employmented as a farmer and has lower education levels than Depok. It is also an impact on the lower income levels in Moyudan Districts. Aim Determine whether socioeconomic, attitudes and behavior factors affect the Free Larvae Index as an indicator of the successfully of dengue prevention program. Method This type of research is descriptive analytic with cross sectional study design. The study population was resident in Sumber Sari subdistrict, District of Moyudan and Catur Tunggal subdistrict,District of Depok, Sleman, Yogyakarta. Samples used in this study were 237 respondents with age characteristics between 17-79 years. Analysis of the data using Spearman correlation analysis and contingency coefficients with SPSS for windows. Result Depok husband's employment had a p value 0.019 while the attitudes and behavior have the p value 0.000, which means there is a significant relationship between husband's employment (r = 0.383), attitude and behavior (r = 0.372) of the Free Larvae Index in Depok District. Likewise found in Moyudan District with p value 0.014 (r = 0.357) for husband’s employment, while attitudes and behaviour have the p value 0.000 (r = 0.522). Conclusion Husband's employment, attitude and behavior are three factors that play a role in determining the Free Larvae Index as an indicator of Dengue Hemorrhagic Fever prevention program. Moyudan District is an area with Free Larvae Index is higher than the Depok districts.