This study is aiming to test the influence of Gross Regional Domestic Product, Consumer Price Index, and Investment on Unemployment in Special Region of Yogyakarta. The population of the research is comprised of 5 regencies, applying the secondary data for 1985 to 2014 period originating from the Statistic Center Board (BPS), Bank Indonesia (BI) and Cooperation and Investment Board (BKPM) of Special Region of Yogyakarta. Data analysis applies Partial Adjustment Model (PAM) of Eviews7 program. Based on the analysis that have been made the results that gross regional domestic product, consumer price index and investment are significant effect on unemployment.