This study aims to determine the effect of capital structure, multiple large shareholder structure, and profitability on firm value. In this study the object used as sample was manufacturing companies which are listed in Indonesia Stock Exchange (IDX) for the period 2015-2017. The sample collection technique has been done by using purposive sampling, so that the final sample obtained was 25 companies listed in Indonesia Stock Exchange for the period 2015-2017. Data collection methods used in this study is a non-participant observation. Sources of data in this research is secondary data obtained from ICMD and www.idx.co.id. Data analysis technique used is multiple linear regression. The statistic test instrument uses EVIEWS 8.0 version which is carried out to perform classic assumption test, multiple linear regressions analysis, and the hypothesis test. Based on the analysis that has been carried out the results show that the capital structure has negative effect, but insignificant on firm value, multiple large shareholder structures has positive effect and significant on firm value, institutional ownership has negative effect, but insignificant on firm value, and profitability has positive effect and significant on firm value.