EXECUTIVE ADVANCE STEPS ADEKUAT APPROACH TO SPATIAL MEMORY AND BRAIN BRAIN STRUCTURE CONGGUIDE HYPOTHYROID
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Hypothyroidism leads to impaired growth and development of the nerves. Stimulus of physical activity, physical exercise will increase blood flow and neurogenesis and synapse plasticity. This study aims to prove the rapid physical activity of the road can improve thyroid function and memory and the number of purkinje cell cerebellum of congenital hypothyroid rat at the time of growth. The design of this study was an experiment on animals testing control group post. The subjects of the study were mice born from 0.05% parent 0.05% induced propylthiouracil (PTU) hypothyroid mother in drinking water from 5th to 15th postnatal pregnancy. The group of training mice began to be trained to walk on a rotating wheel that could spin if a mouse walked. After the age of 1 month of walking practice on the treatmill with a 20-meter / minute son, up to 2 months old mice. A total of 5 normal and hypothyroid mice were taken at the age of 15 days to measure free T4 (fT4) by Elisa method. T4 is freely measured again when a 2-month-old mice. The Morris Water Maze (MWM) test was performed after a 1.5-month-old mouse. The learning was done 3 days in a row each of 4 experiments on 4 quadrants. MWM test is done again 1 time on 3 days and 7 days later to know the memory retention of rats. Used the fastest time a mouse can do every day and averaged. Observation of purkinje cerebellum cell number by using 40x magnification microscope of 2067μm2 wide field of view. Data were analyzed with Anova. Postes of mean fT4 (ng / dL) normal mice, normal exercise, hypothyroid, hypothyroid exercise, hypothyroid thyroxine, and hypothyroid thyroxine exercises were 1.32 ± 0.20, 1.77 ± 0.11, 0.50 ± 0.09, 1.46 ± 0.37, 1.50 ± 0.2 and 1.20 ± 0.33 (p <0.05). The latent learning phase, memory retention of 3 days and 1 week of exercise group and thyroxine and thyroxine exercise were significantly faster than the non-exercise group (p <0.05) .The conclusion of this study is that physical exercise improves cognitive learning and memory, and increases cell numbers purkinje cerebellum of konginetal hypothyroid rat.