The incidence of tuberculosis disease is a public health problem, although there are standards oftherapy and clinical pathway for TB patients. Complications of TB disease will lead to increasemortality and to decrease quality of life of patients. The effectiveness of drug therapy should beenhanced by developing an educational or counseling model as non-pharmacological treatment ofprimary care. Preparation of that model start with knowing factors that influence the success oftuberculosis therapy in primary care. This step is needed to make the model effective and inaccordance with the service condition. The purpose of this research is to know the factorsinfluencing the success of tuberculosis therapy in primary care as the first step to formulate theintervention model of behavior change of Tuberculosis patients. The study design was a cohortfor 4 months with a total of 40 early tuberculosis patients. Data collection was done in primary byinterviewing with questionnaire guidance. Secondary data retrieval was conducted to obtaintherapeutic data, clinical outcomes, laboratory and radiology. The results showed family supportfactors, medication adherence, companion to take medication from family and good nutritionintake have an effect on the success of tuberculosis therapy. Tuberculosis pharmacologic therapyshould be supplemented with family support, medication adherence, companion taking of family-derived medication and good nutritional intake The conclusion showed the most patient haspulmo tuberculosis (61.9%), age <50th (81%), and woman (52,4%). Mineral (Fosfor) fromnutrition intake factors have relationships in tuberculosis theraphy (p = 0.014 ; p <0,05).