The purpose of this research is to analyze the effect of minimum wages, population and also inflation of unemployment in 10 Regency/City in West Section Central Java Province Period 2012-2017. The research was done using data secondary in the form of panel of cross time period 2012-2017 and cross place in 10 Regency/City in West Section Central Java Province Period 2012-2017. The method used estimate this regression was the Random Effect Model (REM). The regression showed that the variabel of minimum wages haven't significant effect on the unemployment in 10 Regency/City in West Section Central Java Province Period 2012-2017. Meanwhile, variabel of population and inflation has positive and significant effect of unemployment in Regency/City in West Section Central Java Province Period 2012-2017.