Background: The healthy eyes are the needs of every human being. If disorders are found in someone’s eyes, their quality of life would be decreasing. One of diseases that might distract human’s visual function is glaucoma. There are many factors which cause the decrease of glaucoma patient’s quality of life. This research aims to discover the correlation between the numbers of anti-glaucoma eye drop kinds used by glaucoma patients with the glaucoma patients themselves. Method: This research was an observational-analytic research with cross sectional approach. The number of sample was 51 patients with the range of age between 20-70 years old by randomly selecting the glaucoma patients in the Eye Clinic RSUD Kota Yogyakarta. The independent variable in this research is the number of the kind of anti-glaucoma eye drop while the dependent variable is the glaucoma patients’ quality of life. The controlled confounding variables includes age, non-pharmacological therapy for glaucoma, and the length of suffering glaucoma. The variables are measured by using questionnaires GQL- 15. The data are analyzed by using Spearman Rank Test. Result: The measurement result of the correlation between the dependent variable and the independent variable by using Spearman Rank Test found that the signification value of 0,363. Conclusion: There wasn’t any significant correlation between the numbers of anti-glaucoma eye drop kinds with the primary glaucoma patients in RSUD Kota Yogyakarta.