Background: The success of the antiretroviral treatment regimen is determined by the high compliance of PLWHA. Compliance with people living with HIV in undergoing an antiretroviral treatment regimen can be influenced by various factors. At LSM Victory Plus Yogyakarta from 3908 PLHIV who underwent therapy, 583 PLWHA did not comply with the treatment. Objective: to analyze factors that influence adherence to antiretroviral treatment in people with HIV / AIDS in Yogyakarta. Method: This study used a qualitative method with a phenomenological approach. The study respondents were 7 people, the sampling technique was purposive sampling with the criteria that all participants were undergoing treatment and adhering to antiretroviral treatment. Data collection by means of in-depth interviews assisted with instruments in the form of interview guides containing open questions, field notes. Analysis of research data using 7 steps Collaizi. Results: There were 9 themes related to factors that influence adherence to antiretroviral treatment in PLWHA in Yogyakarta, namely; openness of patient status to ARV treatment, family support for ARV treatment, peer support for antiretroviral treatment, discriminatory behavior against antiretroviral treatment, feelings during undergoing antiretroviral treatment regimens, knowledge regarding antiretroviral treatment regimens, participant perceptions of antiretroviral drugs, perceptions of beliefs and beliefs in regimens therapy, and easy access to services for participant treatment regimens. Conclusion: ODHA's self-disclosure regarding status influences PLWHA to adhere to treatment, discrimination affect ODHA adherence in treatment, level of boredom about treatment affect ODHA adherence to treatment, knowledge of PLWHA regarding ARV treatment adheres to medication, perceptions of PLHIV about the benefits of ARVs influence ODHA to comply treatment and then the perception of PLWHA about the side effects of ARV affect the compliance of PLWHA in treatment, perceptions of beliefs and beliefs of ODHA related to treatment affect PLWHA to adhere to treatment, ease of access to services affects PLWHA to adhere to treatment, family support factors influence ODHA to adhere to treatment, peer support affects PLWHA for treatment.