Background: Islamic caring is a form of caring that is based on Islamic values in accordance with the guidance of the Qur'an and Hadith. Many caring behaviors that have not been fulfilled, including caring in the context of Islam in Indonesia, which most people adhere to Islam, giving rise to many perceptions of patients who receive nursing care. Research Objective: This study aims to determine the patient's perception of Islamic caring nurses in the Sharia hospital in Yogyakarta. Method: This study uses descriptive qualitative methods. Data collection uses in-depth interviews. The participants in this study amounted to 10 people who were admitted to the PKU Muhammadiyah Yogyakarta hospital and Nur Hidayah Bantul Yogyakarta hospital. Participants were determined using purposive sampling. The validity of the data uses source triangulation and researcher triangulation. Data analysis using qualitative data processing software. Results: The results of this study show patients 'perceptions of nurses' Islamic caring. Found 4 themes from this research, namely Islamic nurses, giving spiritual support, services based on Islamic Shari'a and satisfying nursing services. Islamic nurses who include patience, friendliness, courtesy and care; giving spiritual support includes giving prayers and remembrance, worship, motivational support and collaboration with spiritual formation. Services based on Islamic law include guarding the genitals, carrying out actions according to the law, and differences in the level of understanding of Islamic Islamic Shari'a for each person, while satisfying nursing services which include satisfying services and expected nursing services. Conclusion: Patients feel happy and satisfied when receiving good care and supported by the foundation of Islamic values. It is expected that sharia-based hospitals can comprehensively apply Islamic Sharia.