Introduction: Bone continually experiences rejuvenation, which requires calcium and vitamin D. Mineral storage in bones will peak (Peak Bone Mass or PBM) around the age of 20-30 years. As time goes on, the absorption of calcium decreases and it will smooth the bone tissue. In postmenopausal women, bone fragility is better with bone formation, and this causes osteoporosis to occur in women. WHO reports that broken bones cases caused by osteoporosis will increase from 84,000 in 1986 to 6.26 million in 2050. Method: This research is a case control study between the state of a person with certain risk factors. The samples were 4 postmenopausal women with low mineral levels and 30 postmenopausal women with normal mineral levels. Bone mineral indicators were analyzed by ANOVA and The alternative (if data is not normal) was analyzed using Kruskal Wallis test to see the correlation to bone loss. Result: The p value from bivariat test is 0.003, it means that there is a correlation between mineral levels in bone with the risk of Bone Loss in postmenopausal woman. Conclusion: There is correlation between mineral levels in bone with the risk of Bone Loss in postmenopausal woman.