Background: Dengue is a pandemic and endemic disease that often appears in many parts of the world, especially in tropical and subtropical countries (Wahyuni & Sabir, 2011). Dengue Hemorrhagic Fever (DHF) itself is a disease caused by dengue virus that is transmitted to humans through the bite of Aedes aegypti and aedes albocaliptus mosquitoes. DHF has become a problem for the international community in children. Platelet profile is one of the laboratory parameters needed for the development of dengue infection. Research Methods: This study is a retrospective analytic with cross sectional design. The research sample used was all pediatric patients aged 5-14 years with a diagnosis of dengue hemorrhagic fever at the RSUD in Yogyakarta City who collected 191 samples. Inclusion criteria are children diagnosed with dengue haemorrhagic fever, asking for 5-14 years and medical records with platelet counts. Research Results: Spearman test results obtained with a value (p = 0.368) and (r = 0.065), which means that the correlation is not meaningful, with the strength of a weak correlation. Conclusion: It was found that there was no significant relationship between platelet profiles and the diagnosis of dengue hemorrhagic fever in children aged 5-14 years in RSUD Kota Yogyakarta