Background: One problem that often occurs in childhood is an accident or injury. Injury is one of the main causes of morbidity and mortality of children in the world. Injury prevention actions in the form of supervision that can be done by parents, because children do not pay attention in activities danger. Safety training as an activity that ensures the creation of safe conditions, avoid physical and mental disorders through coaching and training, direction, and control of the implementation of activities that can be done by parents. Objective: Based on the above, the author is interested in studying is there any influence "Safety Training" on parenting skills in handling injury toddlers in the household. Methodology: This research use quasy experimental study with control group design. Sample obtained by using simple random sampling that parents in the village Caturbinangun Widodomartani Ngemplak Sleman. This research was conducted in July 2016. Data collection research using the checklist. Statistical test in this research use Paired T-Test dan Independent T-Test. Result: Research result shows that the influence safety training for skills parents in handling infants injured in households with Paired T-Test results of pre-test and post-test in the intervention group p = 0.001 (p <0.05), while the results of pretest and posttest control group p = 0.568. Independent T-Test test in the intervention and control groups received the pre-test p = 0.337 (p> 0.05) and the results of post-test p = 0.001 (p <0.05). Conclusion: parenting is done entirely by parents, because at this time a child is much more to be missed in a family environment.