Albumin is a major protein component in plasma so that the occurrence of albumin deficiency (hypoalbuminemia) can result in failure in regulation of osmotic pressure and manifest in the occurrence of edema. The use of albumin is one of the treatment options for this condition.Until now, the use of albumin is still be a controvercy because of the high costs and the limited availability. Therefore, this study was carried out with the aim to see an overview of the effectiveness of albumin use and see the difference effectiveness of of albumin treatment in various conditions of patients in PKU Muhammadiyah Gamping Hospital. The study was a non-eksperimental study with descriptive observational design. The process of data collection was carried out retrospectively with a cross-sectional study design in the medical record of patients who received albumin at PKU Muhammadiyah Gamping Hospital in the period 2015-2017. The total population of 75 patients with research samples that met the inclusion criteria was based on a total sampling of 58 patients. Analysis of albumin effectiveness was seen from the increase in albumin levels with a statistical test methods is wilcoxon test with a sample size of 58 patients, while the analysis of effectiveness between the conditions of patients with a statistical test methods is paired sample t test for the number of patients with a diagnosis of at least 3 patients. The results showed that administration of albumin preparations in hospitalized patients at PKU Muhammadiyah Gamping Hospital in the period 2015-2017 effectively increased the patient's albumin level (p <0.05) while the results of the analysis of differences between patient conditions indicate that administration of albumin preparations effectively increases albumin levels significantly in patients with diabetes mellitus (p <0.05) but was not significant in neoplasm patients, stroke, anemia, cerebral infarction, and disorders of plasma protein metabolism (p> 0.05).