Background: The increasing number of elderly population accompanied by increasing problems faced by elderly people also has an impact on decreasing the quality of life of the elderly, such as a decrease in mental capacity, changes in social roles, senility, and depression. This study aims to determine whether there is a meaningful difference between before the provision of Islamic spiritual services and after the provision of Islamic spiritual services with the quality of life of geriatric inpatients in PKU Muhammadiyah Gamping Hospital, Yogyakarta.. Method: This research is a quantitative-analytic study with a quasi-experimental research design with a pretest & posttest assessment. A sample of 106 people with a age range of 60-70 years was chosen using consecutive sampling techniques that met the inclusion criteria. The independent variables studied were Islamic spiritual services while the dependent variable studied was the quality of life of geriatric inpatients. Confounding variables controlled included physical activity, social activity, pain, daily activities, mental health, gender, education level and multimorbidity. Variables were measured using the OPQOL-Brief questionnaire. Data were analyzed using the Wilcoxon test. Results: The measurement results have significant differences between the dependent variable and the independent variable using the Wilcoxon test obtained a significance value of 0,000. Conclusion: There were significant differences in the quality of life of geriatric inpatients before the provision of Islamic spiritual services and after the provision of Islamic spiritual care.