Law No. 40 of 2009 states that pharmacy services at hospitals must obey Pharmaceutical Service Standards, the technical implementation of which is regulated in the Minister of Health Regulation. The latest Minister of Health regulation that regulates pharmaceutical service standards specifically for clinical pharmacy is the Minister of Health Regulation No. 72 of 2016 concerning Standard Pharmaceutical Services at Hospitals. DR M. Yunus Regional General Hospital of Bengkulu is the highest referral hospital in Bengkulu Province with two pharmacists in the structural position and nine pharmacists in the functional position. This study aims to determine the profile of the implementation of clinical pharmacy services in DR M. Yunus Regional General Hospital of Bengkulu based on Minister of Health Regulation No. 72 of 2016. This study was a descriptive-observational study with a cross-sectional approach. The study was conducted at DR M. Yunus Regional General Hospital of Bengkulu. Data collection was carried out through questionnaires to four pharmacists who performed clinical pharmacy services and worked at least 10 years in the DR M. Yunus Regional General Hospital of Bengkulu and observation of document implementation of clinical pharmacy activities as supporting data. Clinical pharmacy services that have been applied in the DR. M. Yunus Regional General Hospital of Bengkulu based on Minister of Health Regulation number 72 of 2016 is 9 activities from 11 clinical pharmacy activities that are guided. The overall percentage of clinical pharmacy services applied is 81.8%. The percentage of each clinical pharmacy activity is prescription study and service, history of drug use history, drug reconciliation, drug therapy counseling and monitoring have reached a percentage of 100% (fully implemented). While for the four activities that did not meet the 100% percentage (not yet fully implemented) were PIO 87.5%, visite 50%, MESO 33.3%, Dispensing Sterile Preparations 66.67% and for two other clinical pharmacy activities namely EPO and PKOD has not been implemented.