This study aims to analyze the influence of macroeconomic variables consisting of inflation, which in this case uses the consumer price index, the exchange rate (exchange rate) of the rupiah measured using the mean rate, the money supply, and interest rates as measured by the BI rate for IFR Sukuk growth. The type of research used is quantitative research with samples of IFR Sukuk growth data for the period 2010 - 2017 which are OLS time series data, using multiple linear regression analysis tools that are processed using software eviews 9. Results obtained from partial analysis that inflation has no effect on IFR Sukuk growth; the rupiah exchange rate has a positive and significant effect on the growth of IFR sukuk; the money supply has a positive and significant effect on the growth of IFR sukuk; and sukuk interest has a negative and significant effect on the growth of IFR sukuk. While simultaneously all independent variables affect the dependent variable.