This study aims to see how much influence Population, Regional Original Revenue (PAD), Regency / City Minimum Wage (UMK), Human Development Index in regencies / cities in Yogyakarta Special Province on the Open Unemployment Rate. This research was conducted by taking data from BPS in the form of secondary data, and using the panel data method, namely through a combination of four districts and one city in the Special Region of Yogyakarta. Based on the results of the study it can be concluded that the majority of the independent variables affect the open unemployment rate except the Regional Original Income which has no influence and is not significant to the Open Unemployment Rate.