Research on the knowledge, attitudes and actions of farmers in the management of pests and diseases of cassava (Manihot esculenta) in Ponjong District, Gunungkidul Regency, Yogyakarta is not yet available, so research is needed to obtain this information. This research aims to determine the level of knowledge, attitudes and actions of farmers in relation to the management of pests and plant diseases, in order to support integrated pest control systems and sustainable cassava production systems. This research was conducted using a survey method with structured interviews directly to farmers using a questionnaire. The selection of the study area was carried out using the purposive sampling method, which consisted of 10 villages. Whereas the determination of the number of respondents was carried out by the quota sampling method. The number of respondent farmers is 5 farmers per village. In total there were 50 respondent farmers. Data obtained from interviews were then analyzed with the Microsoft Office Excel program 2016. Data analysis was carried out descriptively to explain the knowledge, attitudes, and actions of farmers.. Then to see the relationship between age, education level, length of farming experience and participation of farmer groups on farmers' knowledge, attitudes and actions, the χ2 (chi-square) test was carried out at α = 5% level. The knowledge, attitudes and actions of cassava farmers in Ponjong Subdistrict were not influenced by the age, level of education, length of farming experience and participation of farmer group members, but it were influenced by habits or cultures that had been passed down from the more experienced farmers.