EFFECT OF AIR FRESHENER EXPOSURE ON THE HISTOLOGY CORNEA OF RATTUS NORVEGICUS
NASTITI, CHANDRA AYU
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Air freshener is increasingly being used in the community.. Air freshener potentially detrimental to health if its use is not wise. Air freshener containing hazardous compounds include formaldehyde that potentially irritate the cornea of the eye. This study aims to reveal the effect of air freshener exposure on the histology cornea. Subjects of this research were 30 rats Rattus norvegicus, divided into 3 groups: 1 control group (K) and the 2 treatment groups. The treatment given is exposure gel air freshener (group P1) and exposure to spray air freshener (group P2). The duration of exposure starts 15 minutes morning and evening when the mice aged 8 days. The duration increased by 15 minutes per week for a total duration of 4.5 hours during the 67-day-old mice. On day 68 mice were sacrificed to take corneas of his eyes. Corneal histology preparations made by the method of paraffin blocks, Eosine Hematoxylin staining techniques. Histological changes observed are the thickness of the cornea, anterior cornea epithelial thickness and number of keratocytes. Statistics Kruskal Wallis test the thickness of the cornea, followed by Mann Whitney test showed significant differences that P1> K, P2> K. The thickness of the anterior corneal epithelium showed K<P1<P2 but the difference was not significant in One Way ANOVA test. Tukey test showed significant differences in the number of keratocytes K <P1, K <P2 and P1> P2. It was concluded that exposure of air freshener gels and sprays have negative effects on the histology cornea of Rattus norvegicus.