This research aims to describe the formation strategy of entrepreneurship spirit of students, analyze the entrepreneurship spirit and interest of agribusisness entrepreneurships’s students and the factors that affect it. This research use descriptive quantitative method involving 50 students. Primary data was collected by using questionnaire, interview, and observation. Meanwhile, secondary data obtained from the islamic boarding school. Build of agribusiness entrepreneurship to khalafi’s students and salafi’s students using strategy that consist of three steps, such as: students’s recruitment, students’s placement, and displacement level. Entrepreneurship spirit of khalafi’s students and salafi’s students classified in high and very high category. The older students, the higher courage in risk-taking; the higher family environment on agribusiness sector, the higher level of task and results orientation; and the higher students’s social interaction in the boarding school, the higher trust, task and results orientation, leadership, and risk-taking. Interest of agribusiness entrepreneurship’s students classified in high category. Male students have an interest of agribusiness entrepreneurship higher than women. The higher motivation of entrepreneurship’s students, the higher interest of agribusiness entrepreneurship.