Abstract. Bone is continually experiencing rejuvenation, which requires calcium and vitamin D. Mineral storage in bones will peak (Peak Bone Mass or PBM) around the age of 20-30 years. As time goes on, the absorption of calcium decreases and it will smooth the bone tissue. In postmenopausal women bone fragility is better with bone formation, and this causes osteoporosis to occur in women. WHO reports that broken bones caused by osteoporosis will increase from 84,000 in 1986 to 6.26 million in 2050. This research was a case control study. Samples size were 34 postmenopausal women. Data was analyzed by chi-square to see the correlation mineral levels to bone loss and the strength of the association between factor and outcome was determined as an odds ratio (OR). There is correlation between mineral levels with Bone Loss in postmenopouse woman with p value 0.018 and have possibility (OR=12.000; CI 95%= 1.623 – 88.702). The odds ratio show that the risk to bone loss in low mineral subjects was 12 times compared with normal mineral subjects. Need to provide additional calcium for postmenopausal women to increase mineral levels so that they avoid bone loss.