Background: Stroke is a cardiovascular disease associated with interruption of blood supply to the brain due to blocked or damaged blood vessels. This results in disruption of brain function, causing symptoms such as weakness of the limbs, impaired vision, difficulty speaking, and other disorders 1,2. Complications of a stroke will have an impact on the decline in physical, psychological, and social functions, which will cause a decrease in the quality of life. Rehabilitation is one of the solutions that can be done to reduce the impact of stroke so it is expected that the quality of life can be improved 2,3. Research Objectives: To analyze the relationship between rehabilitation adherence with the quality of life of post-stroke patients based on WHOQOLBREF. Method: This study used a cross-sectional study design. Sampling was done in RSJD. Dr. RM. Soedjarwadi by acidental sampling technique that matches the inclusion and exclusion criteria with a sample of 125 subject. The instruments in this study were demographic data questionnaire, Moronsky Medication Adherence Scale (MMAS), and WHOQOL-BREF. The Spearman correlation test and the contingency coefficient were used to analyze the relationship between two variables. Results: Most of subjects were included in the category of late elderly namely in the range of 56-65 years (35.2%), had male sex (64%), worked (64%), had elementary school education (32.8%), and had undergone rehabilitation for 2 -6 months (37.6%). The relationship of rehabilitation compliance with quality of life obtained a significance value (p value) of 0.001 (p <0.05) and a value of r = 0.0390 which means a positive correlation with a weak strength correlation. Conclusion: There is a significant weak relationship between rehabilitation adherence with the quality of life of patients after stroke in based on the WHOQOL-BREF test.