This research is to find out the effectiveness and how much cow bone nano and oil palm empty fruit bunch nano can replace SP-36 and KCl fertilizer on the growth and yield of Cianjur fragrant pandan rice. This research was carried out in January - July 2019, using a single factor experimental design which was arranged in a Completely Randomized Complete Design (RCBD) with 4 treatments. The treatments tested were: A = Control (Fertilizer P, K recommended dosage), B = Fertilizer P 50% recommended dose + Beef Nano concentration 0.2%, C = Fertilizer K 50% recommended dose + Nano TKKS concentration 0 , 2%, and D = Fertilizer P, K 50% recommended dose + Nano Bovine Bone concentration of 0.2% and Nano TKKS 0.2%. Each treatment was repeated 3 times so that there were 12 experimental units. The parameters observed were plant height, number of tillers, number of productive tillers, leaf area, canopy wet and dry weight, root length, root wet and dry weight, percentage of empty and filled grain, weight of 1000 seeds, number of grains per panicle, panicle length, Rice Results. Characterization of bovine nano fertilizer particles and OPEFB each had a particle diameter size with an average size of 255.16 nm and 283.16 nm. The results showed that 50% recommended dosage of Fertilizer P and K + Nano Bovine Bone concentration of 0.2% and Nano TKKS concentration of 0.2% had no significant effect on plant vegetative growth, but had a significant effect on increasing the percentage of filled grains and empty grains . And can increase the yield of milled unhusked rice reaching 7,266 tons. And the dosage of spraying nano cow bone ash fertilizer by 15.38% and oil palm empty fruit bunch ash by 14.35% with a concentration of 0.2% can replace the SP-36 dose by 50% and KCl by 50%.