Tobacco epidemic is one of the biggest public health problem globally. The World Health Organization (WHO) developed MPOWER (monitoring-protecting-offering-warning-enforcing-raising) strategy to defeat the global tobacco epidemic. Smoking prevalence in Indonesia is ranked as the third highest in the world. In order to support the global and local initiatives in defeating tobacco epidemic, a comprehensive smoking cessation clinic at UMY primary care clinic was recently established, consisting of various services, particularly a meridian-based tapping technique with a spritual approach recently introduced, called Spiritual Emotional Freedom Technique (Spiritual-EFT or SEFT).