Philanthropy is one of the most significant Islamic teachings, and it has been practiced by Muhammadiyah, one of Indonesia’s moderate Islamic organizations. As the pandemic of Covid-19 broke out, many parties — including Muhammadiyah — were motivated to get involved in handling it. This research aims to reveal the consistency of Muhammadiyah in Islamic philanthropy through what has been done and is being done to overcome the Covid-19 pandemic and the extent of its impact in the broader community. For this purpose, the descriptive-analysis method is employed in its writing. Among the findings of this study is that in the Covid-19 issue, Muhammadiyah has contributed significantly and continues to take a significant role in overcoming it. Among other things, Muhammadiyah has formed the Muhammadiyah Covid-19 Command Center (MCCC), which is a special team formed to handle Covid-19. This team has been working since it was founded and continues to work on this case. The results of the work included assistance in the field of health, education, and the social sector. Besides, through the Tarjih and Tajdid Assembly, Muhammadiyah has provided religious guidance for its members during this pandemic so that they are not confused about practicing worship. The impact of these programs and actions is that the members of Muhammadiyah, and in general, the wider community, receive significant assistance in the health, education, social and religious fields.