Economic development is a policy intervention endeavor aming to improve the well being of people, economic growth is a phenomena if market productivity and rise in GDP. To increase the well being of people, some internal and external factors might affect. This research aims to investigate the effect of CO2 emiision, energy usage, FDI, and health expenditure on GDP per capita in the ASEAN countris from 2008- 2018. The research used panel data method that combined time series and cross section data using Eviews 7 program. Based on the analysis that has been done, the results of the study show that CO2 emissions have a positive and significant effect on GDP per capita, energy use has a positive and significant effect on GDP per capita, PMA and health expenditure have a positive and significant effect on GDP per capita. policies in order to control environmental damage, companies must pay taxes to reduce CO2 emissions and social responsibility and also reduce fossil fuels and switch to more environmentally friendly energy to protect the environment and society, and also the government is expected to ease bureaucracy and contracts for companies foreign investment in order to stimulate stable foreign investment so that it can affect economic growth.