The role of nurses is huge in conducting nursing care under the existing Standard Operational Procedure (SPO). If it complies with the established standards, then the incident almost injured or even the KNC did not occur. Job stress can occur in nursing care for patients. Workloads which include quantitative workloads, qualitative workloads, physical workloads, psychological workloads, social workloads. This study aims to determine the effect of work stress on nurses' workload on the incidence of near injury / KNC and its impact on the performance of nurse's inpatient installations. This type of research is quantitative research with a cross-sectional approach. The population is all nurses in the Inpatient Services at Kudus General Hospital. Sample 68 nurses, using total sampling. This type of research is quantitative research with a cross-sectional approach. Based on the data processing that has done, the results can be used to answer the hypothesis in this study. Hypothesis testing in this study was conducted by looking at the value of T-Statistics and the value of P-Values. The research hypothesis can be accepted if the P-Values value < 0.05. Hypothesis 1: Near Miss, Events Affecting Performance P Values 0.009 results are acceptable; Hypothesis 2 Stress affecting Near Miss Events/KNC P values result in 0.008. Hypothesis 3 Stress affecting performance P values 0,035 are acceptable.