Nurse turnover is a serious challenge to the efficiency and effectiveness of health services, because it harms the organization both in terms of costs, resources and motivation of nurses. Work stress and workload will affect emotions, thoughts, physical conditions, including the ability to control, so that it affects their desires out of the organization. Industrial turnover also increases if the work environment is not supportive, thus organizational commitment also decreases. The purpose of this study was to determine the effect of work stress, workload, and work environment on turnover intention through organizational commitment to nurses. Research is an explanatory research. Subjects were 142 nurses at Aisyiyah Kudus Hospital. In this study the total sampling method was used. Data collection is done by questionnaire. The data analysis technique used is Structural Equation Model (SEM). The results showed there was a negative influence of work stress (cr = -2,274, p = 0.023) and workload (cr = -2,218, p = 0.027) and a positive influence of the work environment (cr = 2.104, p = 0.035) on organizational commitment. There is a positive influence of work stress (cr = 2.018, p = 0.044) and workload (cr = 2.229, p = 0.022) and a negative influence of the work environment (cr = -2.371, p = 0.018) on turnover intention. There is a negative influence on organizational commitment to turnover intention, with a cr of -2.454 with p of 0.014. The results of the path analysis found work stress, workload, and work environment directly affect turnover intention.