Epidemiological data showed an increased prevalence of chronic pain and weakness in the elderly. One of the chronic diseases that can cause the sensation of pain in the elderly is Rheumatoid Arthritis (RA). In addition, the elderly are particularly susceptible of degenerative joint diseases such as osteoarthritis which has characterized by pain in the lower extremities, decreased muscle function, and mobility that can degrade the quality of life. Non-pharmacological modality therapy is a component of multimodal management that very important for pain management, including Ergonomic Exercises. The aims of the study was to determine the effect of activity therapy ergonomic exercises to decrease joint pain scale, and to increase muscle strength in elderly with joints degenerative at work area Kasihan II Public Health Center, Bantul, Yogyakarta. Method : Quasi-experimental with pretest-posttest control group design was carried out in this study. The study was done in three village of Bantul district (Padokan Lor, Jomegatan and Onggobayan). Purposive sampling was used to identify the study subjects. A sample of 50 elderly was included in the study for experimental (17) and control (33) groups. Sampling technique used purposive sampling. T-test, Wilcoxon, and two sample Wilcoxon rank-sum, tests were used to analysis the data. Results : During the four weeks intervention of ergonomic exercise, there were significant decreases in scale joint pain in elderly with degenerative joint by P value 0.000 (α <0.05), and increases in muscle strength by P value 0,002 for muscles pull and P value 0,0001 for muscles push. Discussion : Activity therapy of an ergonomic exercise has significant influence to decrease joint pain scale and to increase muscle strength in elderly with degenerative joints.