This study is to analyze the influence of Capital Adequacy Ratio (CAR), Financing Deposit to Ratio (FDR), Non-Performing Financing (NPF), Operating Expenses Operating Income (BOPO), and Quick Ratio (QR) on Return on Assets (ROA) of Bank Syariah Mandiri. The sampel in this study is Bank Syariah Mandiri. The analysis used in this study is an analysis of linear regression. The data used of the multipe linear analysis are panel data which are the financial statements on the first quarter of 2009 until the fourth quarter of 2015. The source of data were taken from the financial statements of Bank Syariah Mandiri. Based on the result of multiple linear analysis test, it shows that the CAR and FDR hand no effect equally to ROA of Bank Syariah Mandiri. NPF and BOPO give significant and negative effect on ROA of Islamic Bank Mandiri while QR gives significantly positive effect to ROA of Bank Syariah Mandiri.