A research aims to understand the influence of the extract of Annona muricata L. leaves on Thrips sp., and determine the best dose of Annona muricata L. leaves extract in controlling Thrips shop on the Chrysanthemum flower. This research was conducted in Panggeran, Pakem, Sleman from April to July 2016. The research was conducted on experimental research with single factor with three replications, which is arranged in a Completely Randomized Design. The treatments consisted of 5 different doses, i.e. 250 g/l of Annona muricata L. Leaves extract was applied every 2 days, 500 g/l of Annona muricata L. leaves extract applied every 4 days, 750 g/l of Annona muricata L. leaves extract applied every 6 days, 500g/l profenofos applied every 6 days, and control. The result of this research showed that applications of Annona muricata L leaves extract, affects in mortality of Thrips sp., and the best dose a extract Annona muricata L was 500 g/l of Annona muricata L. leaves extract applied every 4 days